Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome.

ABSTRACT:

Background

With differences apparent in the gut microbiome in mild cognitive impairment (MCI) and dementia, and risk factors of dementia linked to alterations of the gut microbiome, the question remains if gut microbiome characteristics may mediate associations of education with MCI.

Objectives

We sought to examine potential mediation of the association of education and MCI by gut microbiome diversity or composition.

Design

Cross-sectional study.

Setting

Luxembourg, the Greater Region (surrounding areas in Belgium, France, Germany).

Participants

Control participants of the Luxembourg Parkinson's Study.

Measurements

Gut microbiome composition, ascertained with 16S rRNA gene amplicon sequencing. Differential abundance, assessed across education grou

SUBMITTER: Klee M 

PROVIDER: S-EPMC11060993 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature