Unlocking the specificity of antimicrobial peptide interactions for membrane-targeted therapies.

ABSTRACT: Antimicrobial peptides (AMPs) are increasingly recognized as potent therapeutic agents, with their selective affinity for pathological membranes, low toxicity profile, and minimal resistance development making them particularly attractive in the pharmaceutical landscape. This study offers a comprehensive analysis of the interaction between specific AMPs, including magainin-2, pleurocidin, CM15, LL37, and clavanin, with lipid bilayer models of very different compositions that have been ordinarily used as biological membrane models of healthy mammal, cancerous, and bacterial cells. Employing unbiased molecular dynamics simulations and metadynamics techniques, we have deciphered the intricate mechanisms by which these peptides recognize pathogenic and pathologic lipid patterns and integrate i

SUBMITTER: Conde-Torres D 

PROVIDER: S-EPMC11061258 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature