Endogenous retroelement expression in the gut microenvironment of people living with HIV-1.

ABSTRACT:

Background

Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the human genome. Our previous studies of the interferome in the gut suggest potential mechanisms regarding how IFNb may drive HIV-1 gut pathogenesis. As ERE activity is suggested to partake in type 1 immune responses and is incredibly sensitive to viral infections, we sought to elucidate underlying interactions between ERE expression and gut dynamics in people living with HIV-1 (PLWH).

Methods

ERE expression profiles from bulk RNA sequencing of colon biopsies and PBMC were compared between a cohort of PLWH not on antiretroviral therapy (ART) and uninfected controls.

Findings

59 EREs were differentially exp

SUBMITTER: Dopkins N 

PROVIDER: S-EPMC11061259 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature