Multiple reports on the causal relationship between various chronic pain and gut microbiota: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous evidence suggests a link between gut microbiota and chronic pain, but the causal relationship is not yet fully understood.

Methods

We categorized gut microbiota based on phylum, class, order, family, and genus levels and gathered pain-related information from the UKB and FinnGen GWAS project. Then, we conducted MR analysis to explore the potential causal relationship between gut microbiota and chronic pain at 12 specific locations.

Results

We have discovered a direct connection between genetic susceptibility in the gut microbiota (gut metabolites) and pain experienced at 12 specific locations. Notably, Serotonin (5-HT) and Glycine were found to be associated with a higher risk of pain in the extremities. On the other hand, certain microbial familie

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11061420 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature