Zinc metabolism and its role in immunity status in subjects with trisomy 21: chromosomal dosage effect.

ABSTRACT:

Introduction

Trisomy 21 (T21), which causes Down syndrome (DS), is the most common chromosomal aneuploidy in humankind and includes different clinical comorbidities, among which the alteration of the immune system has a heavy impact on patient's lives. A molecule with an important role in immune response is zinc and it is known that its concentration is significantly lower in children with T21. Different hypotheses were made about this metabolic alteration and one of the reasons might be the overexpression of superoxide dismutase 1 (SOD1) gene, as zinc is part of the SOD1 active enzymatic center.

Methods

The aim of our work is to explore if there is a linear correlation between zinc level and immune cell levels measured in a total of 217 blood samples from subjects wi

SUBMITTER: Ramacieri G 

PROVIDER: S-EPMC11061464 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature