Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women.

ABSTRACT:

Background

Distinguishing ovarian cancer from other gynecological malignancies is crucial for patient survival yet hindered by non-specific symptoms and limited understanding of ovarian cancer pathogenesis. Accumulating evidence suggests a link between ovarian cancer and deregulated lipid metabolism. Most studies have small sample sizes, especially for early-stage cases, and lack racial/ethnic diversity, necessitating more inclusive research for improved ovarian cancer diagnosis and prevention.

Methods

Here, we profiled the serum lipidome of 208 ovarian cancer, including 93 early-stage patients with ovarian cancer and 117 nonovarian cancer (other gynecological malignancies) patients of Korean descent. Serum samples were analyzed with a high-coverage liquid chromatography hig

SUBMITTER: Sah S 

PROVIDER: S-EPMC11061607 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature