MiR-153 promotes neural differentiation by activating the cell adhesion/Ca²⁺ signaling pathway and targeting ion channel activity in HT-22 cells by bioinformatic analysis.

ABSTRACT: MicroRNAs have been studied extensively in neurodegenerative diseases. In a previous study, miR-153 promoted neural differentiation and projection formation in mouse hippocampal HT-22 cells. However, the pathways and molecular mechanism underlying miR-153-induced neural differentiation remain unclear. To explore the molecular mechanism of miR-153 on neural differentiation, we performed RNA sequencing on miR-153-overexpressed HT-22 cells. Based on RNA sequencing, differentially expressed genes (DEGs) and pathways in miR-153-overexpressed cells were identified. The Database for Annotation, Visualization and Integrated Discovery and Gene Set Enrichment Analysis were used to perform functional annotation and enrichment analysis of DEGs. Targetscan predicted the targets of miR-153. The S

SUBMITTER: Jiao L 

PROVIDER: S-EPMC11061740 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature