Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals.

ABSTRACT:

Background

The understanding of the molecular genetic contributions to smoking is largely limited to the additive effects of individual single nucleotide polymorphisms (SNPs), but the underlying genetic risk is likely to also include dominance, epistatic, and gene-environment interactions.

Methods

To begin to address this complexity, we attempted to identify genetic interactions between rs16969968, the most replicated SNP associated with smoking quantity, and all SNPs and genes across the genome.

Results

Using the UK Biobank European subsample, we found one SNP, rs1892967, and two genes, PCNA and TMEM230, that showed a significant genome-wide interaction with rs16969968 for log10 CPD and raw CPD, respectively, in a sample of 116 442 individuals who self-reported curre

SUBMITTER: Romero Villela PN 

PROVIDER: S-EPMC11062023 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature