Uncertainty propagation in absolute metabolite quantification for in vivo MRS of the human brain.

ABSTRACT:

Purpose

Absolute spectral quantification is the standard method for deriving estimates of the concentration from metabolite signals measured using in vivo proton MRS (¹ H-MRS). This method is often reported with minimum variance estimators, specifically the Cramér-Rao lower bound (CRLB) of the metabolite signal amplitude's scaling factor from linear combination modeling. This value serves as a proxy for SD and is commonly reported in MRS experiments. Characterizing the uncertainty of absolute quantification, however, depends on more than simply the CRLB. The uncertainties of metabolite-specific (T_1m , T_2m ), reference-specific (T_1ref , T_2ref ), and sequence-specific (T_R , T_E ) parameters are generally igno

SUBMITTER: Instrella R 

PROVIDER: S-EPMC11062627 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature