Plasma Biomarker Profiles for Premature and Nonpremature Coronary Heart Disease in Women.

ABSTRACT:

Background

Premature coronary heart disease (CHD) is a major cause of death in women. We aimed to characterize biomarker profiles of women who developed CHD before and after age 65 years.

Methods

In the Women's Health Study (median follow-up 21.5 years), women were grouped by age and timing of incident CHD: baseline age <65 years with premature CHD by age 65 years (25 042 women; 447 events) and baseline age ≥65 years with nonpremature CHD (2982 women; 351 events). Associations of 44 baseline plasma biomarkers measured using standard assays and a nuclear magnetic resonance (NMR)-metabolomics assay were analyzed using Cox models adjusted for clinical risk factors.

Results

Twelve biomarkers showed associations only with premature CHD and included lipoprotein(a), which wa

SUBMITTER: Dugani SB 

PROVIDER: S-EPMC11062763 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature