Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is thought to result from complex interactions between the host immune system, microbiota, and environmental exposures. Currently, there is limited data regarding the impact of ambient particulate matter ≤2.5 μm in diameter (PM_2.5) in the pathogenesis of CRS, despite evidence linking PM_2.5 to other respiratory diseases. We hypothesized that PM_2.5 may result in differential cytokine patterns that could inform our mechanistic understanding of the effect of environmental factors on CRS.

Methods

We conducted an analysis of data prospectively collected from 308 CRS patients undergoing endoscopic sinus surgery. Cytokines were quantified in intraoperative mucus specimens using a multiplex flow cytometric bead

SUBMITTER: Lubner RJ 

PROVIDER: S-EPMC11062815 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature