Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites.

ABSTRACT:

Purpose

Radiotherapy (RT) is a widely employed anticancer treatment. Emerging evidence suggests that RT can elicit both tumor-inhibiting and tumor-promoting immune effects. The purpose of this study is to investigate immune suppressive factors of radiotherapy.

Experimental design

We used a heterologous two-tumor model in which adaptive concomitant immunity was eliminated.

Results

Through analysis of PD-L1 expression and myeloid-derived suppressor cells (MDSC) frequencies using patient peripheral blood mononuclear cells and murine two-tumor and metastasis models, we report that local irradiation can induce a systemic increase in MDSC, as well as PD-L1 expression on dendritic cells and myeloid cells, and thereby increase the potential for metastatic dissemination in dis

SUBMITTER: Hou Y 

PROVIDER: S-EPMC11062826 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature