NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2.

ABSTRACT:

Background

Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs can be traced back to primordial germ cells that fail to mature during embryonic development. These cells express high levels of pluripotency factors, including the transcription factor NANOG which is highly expressed in TGCTs. Gain or amplification of the NANOG locus is common in advanced tumours, suggesting a key role for this master regulator of pluripotency in TGCT stemness and malignancy.

Methods

In this study, we analysed the expression of microRNAs (miRNAs) that are regulated by NANOG in TGCTs via integrated bioinformatic analyses of data from The Cancer

SUBMITTER: Cardenas RP 

PROVIDER: S-EPMC11062916 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature