Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer.

ABSTRACT: HPV vaccination with concomitant HPV-based screening of young women has been proposed for faster cervical cancer elimination. We describe the baseline results of a population-based trial of this strategy to reduce the incidence of HPV. All 89,547 women born 1994-1999 and resident in the capital region of Sweden were personally invited to concomitant HPV vaccination and HPV screening with 26,125 women (29.2%) enrolled between 2021-05-03 and 2022-12-31. Baseline HPV genotyping of cervical samples from the study participants finds, compared to pre-vaccination prevalences, a strong decline of HPV16 and 18 in birth cohorts previously offered vaccination, some decline for cross-protected HPV types but no decline for HPV types not targeted by vaccines. Our dynamic transmission modelling predicts

SUBMITTER: Arroyo Muhr LS 

PROVIDER: S-EPMC11063066 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature