Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies.

ABSTRACT:

Background

Schizophrenia is associated with increased risk of developing multiple aging-related diseases, including metabolic, respiratory, and cardiovascular diseases, and Alzheimer's and related dementias, leading to the hypothesis that schizophrenia is accompanied by accelerated biological aging. This has been difficult to test because there is no widely accepted measure of biological aging. Epigenetic clocks are promising algorithms that are used to calculate biological age on the basis of information from combined cytosine-phosphate-guanine sites (CpGs) across the genome, but they have yielded inconsistent and often negative results about the association between schizophrenia and accelerated aging. Here, we tested the schizophrenia-aging hypothesis using a DNA methylation meas

SUBMITTER: Caspi A 

PROVIDER: S-EPMC11063120 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature