Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study.

ABSTRACT:

Aim

To investigate whether age at first sexual intercourse could lead to any changes in the risk of oral cavity cancer.

Methods

A two-sample mendelian randomization was conducted using genetic variants associated with age at first sexual intercourse in UK biobank as instrumental variables. Summary data of Northern American from a previous genome-wide association study aimed at oral cavity cancer was served as outcome. Three analytical methods: inverse variance-weighted, mendelian randomization Egger, and weighted median were used to perform the analysis, among which inverse variance-weighted was set as the primary method. Robustness of the results was assessed through Cochran Q test, mendelian randomization Egger intercept tests, MR PRESSO, leave one out analysis and funnel

SUBMITTER: Sun T 

PROVIDER: S-EPMC11063229 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature