Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation.

ABSTRACT: Introduction: It may take decades to develop cardiovascular dysfunction following exposure to high doses of ionizing radiation from medical therapy or from nuclear accidents. Since astronauts may be exposed continually to a complex space radiation environment unlike that experienced on Earth, it is unresolved whether there is a risk to cardiovascular health during long-term space exploration missions. Previously, we have described that mice exposed to a single dose of simplified Galactic Cosmic Ray (GCR_5-ion) develop cardiovascular dysfunction by 12 months post-radiation. Methods: To investigate the biological basis of this dysfunction, here we performed a quantitative mass spectrometry-based proteomics analysis of heart tissue (proteome and phosphoproteome) and pl

SUBMITTER: Kidane YH 

PROVIDER: S-EPMC11063234 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature