Role of microbiota-gut-brain axis in natural aging-related alterations in behavior.

ABSTRACT:

Introduction

Aging is a complex, time-dependent biological process that involves a decline of overall function. Over the past decade, the field of intestinal microbiota associated with aging has received considerable attention. However, there is limited information surrounding microbiota-gut-brain axis (MGBA) to further reveal the mechanism of aging.

Methods

In this study, locomotory function and sensory function were evaluated through a series of behavioral tests.Metabolic profiling were determined by using indirect calorimetry.16s rRNA sequence and targeted metabolomics analyses were performed to investigate alterations in the gut microbiota and fecal short-chain fatty acids (SCFAs). The serum cytokines were detected by a multiplex cytokine assay.The expression of proinfla

SUBMITTER: Jing Y 

PROVIDER: S-EPMC11063250 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature