Comprehensive pan-cancer analysis of YBX family reveals YBX2 as a potential biomarker in liver cancer.

ABSTRACT:

Background

The Y-box-binding proteins (YBX) act as a multifunctional role in tumor progression, metastasis, drug resistance by regulating the transcription and translation process. Nevertheless, their functions in a pan-cancer setting remain unclear.

Methods

This study examined the clinical features expression, prognostic value, mutations, along with methylation patterns of three genes from the YBX family (YBX1, YBX2, and YBX3) in 28 different types of cancer. Data used for analysis were obtained from Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. A novel YBXs score was created using the ssGSEA algorithm for the single sample gene set enrichment analysis. Additionally, we explored the YBXs score's association with the tumor microenvironment (TME)

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC11063299 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature