Clinical significance of immune-related antigen CD58 in gliomas and analysis of its potential core related gene clusters.

ABSTRACT:

Background

The clinical significance of immune-related antigen CD58 in gliomas remains uncertain. The aim of this study was to examine the clinical importance and possible core related genes of CD58 in gliomas.

Methods

Pan-cancer analysis was to observe the association between CD58 and different tumors, glioma RNA sequencing data and clinical sample analyses were used to observe the relationship between CD58 and glioma, shRNA interference models were to observe the impact of CD58 on glioma cell function, and four glioma datasets and two online analysis platforms were used to explore the core related genes affecting the correlation between CD58 and glioma.

Results

High CD58 expression was associated with worse prognosis in vari

SUBMITTER: Tian Z 

PROVIDER: S-EPMC11063413 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature