Tunable ciprofloxacin delivery through personalized electrospun patches for tympanic membrane perforations.

ABSTRACT: Approximately 740 million symptomatic patients are affected by otitis media every year. Being an inflammatory disease affecting the middle ear, it is one of the primary causes of tympanic membrane (TM) perforations, often resulting in impaired hearing abilities. Antibiotic therapy using broad-spectrum fluoroquinolones, such as ciprofloxacin (CIP), is frequently employed and considered the optimal route to treat otitis media. However, patients often get exposed to high dosages to compensate for the low drug concentration reaching the affected site. Therefore, this study aims to integrate tissue engineering with drug delivery strategies to create biomimetic scaffolds promoting TM regeneration while facilitating a localized release of CIP. Distinct electrospinning (ES) modalities were designe

SUBMITTER: Anand S 

PROVIDER: S-EPMC11063525 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature