The association between depressive symptoms and high-sensitivity C-reactive protein: Is body mass index a moderator?

ABSTRACT:

Objective

Depression and obesity are highly comorbid conditions with shared biological mechanisms. It remains unclear how depressive symptoms and body mass index (BMI) interact in relation to inflammation. This cross-sectional study investigated the independent associations of depressive symptoms and BMI with high sensitivity C-reactive protein (hs-CRP), as well as the moderating role of BMI on the depressive symptoms-hs-CRP association.

Methods

Participants (n = 8827) from the 2015-2018 National Health and Nutrition Examination Surveys were aged ≥20 with a BMI ≥18.5 kg/m², completed the Depression Screener, and had hs-CRP data. Multivariable linear regression was used to analyze hs-CRP in relation to depressive symptoms and BMI. An interaction term was inc

SUBMITTER: Tassone VK 

PROVIDER: S-EPMC11063595 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature