Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.

ABSTRACT:

Rationale

Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of interferon-stimulated genes (ISGs). How asthma-susceptibility genes modulate cellular response upon viral infection by fine-tuning ISG induction and subsequent airway inflammation in genetically susceptible asthma patients remains largely unknown.

Objectives

To decipher the functions of gasdermin B (encoded by GSDMB) in respiratory virus-induced lung inflammation.

Methods

In two independent cohorts, we analysed expression correlation between GSDMB and ISG s. In human bronchial epithelial cell line or primary bronchial epithelial cells, we generated GSDMB-overexpressing and GSDMB-def

SUBMITTER: Liu T 

PROVIDER: S-EPMC11063620 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature