Multimodal Interrogation of Ventral Pallidum Projections Reveals Projection-Specific Signatures and Effects on Cocaine Reward.

ABSTRACT: The ventral pallidum (VP) is a central hub in the reward circuitry with diverse projections that have different behavioral roles attributed mostly to the connectivity with the downstream target. However, different VP projections may represent, as in the striatum, separate neuronal populations that differ in more than just connectivity. In this study, we performed in mice of both sexes a multimodal dissection of four major projections of the VP-to the lateral hypothalamus (VP_→LH), ventral tegmental area (VP_→VTA), lateral habenula (VP_→LHb), and mediodorsal thalamus (VP_→MDT)-with physiological, anatomical, genetic, and behavioral tools. We also tested for physiological differences between VP neurons receiving input from nucleus accumbens medium spin

SUBMITTER: Bernat N 

PROVIDER: S-EPMC11063828 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature