The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease.

ABSTRACT: Here, we used digital spatial profiling (DSP) to describe the glomerular transcriptomic signatures that may characterize the complex molecular mechanisms underlying progressive kidney disease in Alport syndrome, focal segmental glomerulosclerosis, and membranous nephropathy. Our results revealed significant transcriptional heterogeneity among diseased glomeruli, and this analysis showed that histologically similar glomeruli manifested different transcriptional profiles. Using glomerular pathology scores to establish an axis of progression, we identified molecular pathways with progressively decreased expression in response to increasing pathology scores, including signal recognition particle-dependent cotranslational protein targeting to membrane and selenocysteine synthesis pathways. We a

SUBMITTER: Clair G 

PROVIDER: S-EPMC11063942 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature