GTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is a malignant tumor with poor survival rate. G2 and S phase-expressed-1 (GTSE1) takes part in the progression of diverse tumors as an oncogene, but its role and potential mechanism in NPC remain unknown.

Methods

The GTSE1 expression was analyzed by western blot in NPC tissues and cells. Knock-down experiments were conducted to determine the function of GTSE1 in NPC by cell counting kit-8, the 5-ethynyl-2'-deoxyuridine (EdU) incorporation experiment, cell scratch wound-healing experiment, transwell assays, tube forming experiment and western blot. In addition, the in vivo role of GTSE1 was addressed in tumor-bearing mice.

Results

The expression of was increased in NPC. Silencing of GTSE1 suppressed cell viability, the percent

SUBMITTER: Dong J 

PROVIDER: S-EPMC11064356 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature