Genomic analysis of inter-hospital transmission of vancomycin-resistant <i>Enterococcus faecium</i> sequence type 80 isolated during an outbreak in Hiroshima, Japan.

ABSTRACT: Outbreaks caused by vancomycin-resistant enterococci that transcend jurisdictional boundaries are occurring worldwide. This study focused on a vancomycin-resistant enterococcus outbreak that occurred between 2018 and 2021 across two cities in Hiroshima, Japan. The study involved genetic and phylogenetic analyses using whole-genome sequencing of 103 isolates of vancomycin-resistant enterococci to identify the source and transmission routes of the outbreak. Phylogenetic analysis was performed using core genome multilocus sequence typing and core single-nucleotide polymorphisms; infection routes between hospitals were inferred using BadTrIP. The outbreak was caused by Enterococcus faecium sequence type (ST) 80 carrying the vanA plasmid, which was derived from strain A10290 isola

SUBMITTER: Segawa T 

PROVIDER: S-EPMC11064488 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature