N-cadherin and β1 integrin coordinately regulate growth plate cartilage architecture.

ABSTRACT: Spatial and temporal regulation of chondrocyte maturation in the growth plate drives growth of many bones. One essential event to generate the ordered cell array characterizing growth plate cartilage is the formation of chondrocyte columns in the proliferative zone via 90-degree rotation of daughter cells to align with the long axis of the bone. Previous studies have suggested crucial roles for cadherins and integrin β1 in column formation. The purpose of this study was to determine the relative contributions of cadherin- and integrin-mediated cell adhesion in column formation. Here we present new mechanistic insights generated by application of live time-lapse confocal microscopy of cranial base explant cultures, robust genetic mouse models, and new quantitative methods to analyze cell be

SUBMITTER: Greer SE 

PROVIDER: S-EPMC11064670 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature