Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study.

ABSTRACT:

Background

Despite evidence linking viruses and oral microbiome to rheumatoid arthritis (RA), limited whole genome sequencing research has been conducted on the oral virome (a viral component of the microbiome) of untreated RA patients. This pilot research seeks to address this knowledge gap by comparing the oral virome of untreated rheumatoid arthritis patients (RAs) and healthy individuals (HCs).

Method

Whole genome DNA sequence of saliva samples from 45 participants including 21 RAs and 24 age and gender matched HCs was obtained from the BioProject: PRJEB6997. Metaphlan3 pipeline and LEfSe analysis were used for the viral signature detection. Wilcoxon pairwise test and ROC analysis were used to validate and predict signatures.

Results

RA exhibits higher alpha diver

SUBMITTER: Ghorbani M 

PROVIDER: S-EPMC11064737 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature