Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics.

ABSTRACT: Given the increasingly large number of loci discovered by psychiatric GWAS, specification of the key biological pathways underlying these loci has become a priority for the field. We have previously leveraged the pleiotropic genetic relationships between schizophrenia and two cognitive phenotypes (educational attainment and cognitive task performance) to differentiate two subsets of illness-relevant SNPs: (1) those with "concordant" alleles, which are associated with reduced cognitive ability/education and increased schizophrenia risk; and (2) those with "discordant" alleles linked to reduced educational and/or cognitive levels but lower schizophrenia susceptibility. In the present study, we extend our prior work, utilizing larger input GWAS datasets and a more powerful statistical approac

SUBMITTER: Bhattacharyya U 

PROVIDER: S-EPMC11065000 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature