Nitrosative stress under microaerobic conditions triggers inositol metabolism in Pseudomonas extremaustralis.

ABSTRACT: Bacteria are exposed to reactive oxygen and nitrogen species that provoke oxidative and nitrosative stress which can lead to macromolecule damage. Coping with stress conditions involves the adjustment of cellular responses, which helps to address metabolic challenges. In this study, we performed a global transcriptomic analysis of the response of Pseudomonas extremaustralis to nitrosative stress, induced by S-nitrosoglutathione (GSNO), a nitric oxide donor, under microaerobic conditions. The analysis revealed the upregulation of genes associated with inositol catabolism; a compound widely distributed in nature whose metabolism in bacteria has aroused interest. The RNAseq data also showed heightened expression of genes involved in essential cellular processes like transcription, translation

SUBMITTER: Venero ECS 

PROVIDER: S-EPMC11065229 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature