Recent Opioid Use Impedes Range Adaptation in Reinforcement Learning in Human Addiction.

ABSTRACT:

Background

Drugs like opioids are potent reinforcers thought to co-opt value-based decisions by overshadowing other rewarding outcomes, but how this happens at a neurocomputational level remains elusive. Range adaptation is a canonical process of fine-tuning representations of value based on reward context. Here, we tested whether recent opioid exposure impacts range adaptation in opioid use disorder, potentially explaining why shifting decision making away from drug taking during this vulnerable period is so difficult.

Methods

Participants who had recently (<90 days) used opioids (n = 34) or who had abstained from opioid use for ≥ 90 days (n = 20) and comparison control participants (n = 44) completed a reinforcement learning task designed to induce robust contextual modula

SUBMITTER: Gueguen MCM 

PROVIDER: S-EPMC11065633 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature