A cuproptosis-related signature predicts prognosis and indicates cross-talk with immunocyte in ovarian cancer.

ABSTRACT:

Purpose

Cuproptosis, programmed cell death by intracellular copper-mediated lipoylated protein aggregation, is involved in various tumorigenesis and drug resistance abilities by mediating the tumor microenvironment. Previous studies have demonstrated that serum copper levels are higher in OC patients than in normal subjects. However, the exact relationship between cuproptosis and ovarian cancer progression remains to be further elucidated.

Methods

The Cancer Genome Atlas (TCGA) and gene expression omnibus (GEO) datasets were utilized to establish a cuproptosis-related prognostic signature in ovarian cancer. Subsequently, the bulk RNA-seq analysis and single-cell RNA-seq analysis were used to identify the relationship between signature with immune cell infiltration, chemother

SUBMITTER: Yang B 

PROVIDER: S-EPMC11065839 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature