Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis.

ABSTRACT:

Objective

Despite frequent treatment of alcohol withdrawal syndrome (AWS) in the emergency department (ED), evidence for phenobarbital (PB) as an ED alternative therapy is mixed. We conducted a systematic review and meta-analysis comparing safety and efficacy of PB to benzodiazepines (BZDs) for treatment of AWS in the ED.

Methods

We searched articles and references published in English in PubMed, Web of Science, and Embase from inception through May 2022. We included randomized trials and cohort studies comparing treatment with PB to BZD controls and excluded studies focused on non-AWS conditions. Review was conducted by two blinded investigators and a third author; eight of 59 (13.6%) abstracts met inclusion criteria for review and meta-analysis using a random-effects model

SUBMITTER: Lee CM 

PROVIDER: S-EPMC11065966 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature