Detecting language network alterations in mild cognitive impairment using task-based fMRI and resting-state fMRI: A comparative study.

ABSTRACT:

Objective

The objective of this study was to investigate the functional changes associated with mild cognitive impairment (MCI) using independent component analysis (ICA) with the word generation task functional magnetic resonance imaging (fMRI) and resting-state fMRI.

Methods

In this study 17 patients with MCI and age and education-matched 17 healthy individuals as control group are investigated. All participants underwent resting-state fMRI and task-based fMRI while performing the word generation task. ICA was used to identify the appropriate independent components (ICs) and their associated networks. The Dice Coefficient method was used to determine the relevance of the ICs to the networks of interest.

Results

IC-14 was found relevant to language network in both re

SUBMITTER: Kemik K 

PROVIDER: S-EPMC11066416 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature