Effect of dopamine on limbic network connectivity at rest in Parkinson's disease patients with freezing of gait.

ABSTRACT:

Background

Freezing of gait (FOG) in Parkinson's disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the dopamine "OFF" state. While other studies found that dopaminergic replacement therapy alters functional brain organization in PD, the specific effect of dopamine medication on fronto-striato-limbic functional connectivity in freezers remains unclear.

Objective

To evaluate how dopamine therapy alters resting state functional connectivity (rsFC) of the fronto-striato-limbic circuitry in PD freezers, and whether the degree of connectivity change is related to freezing severity and anxiety.

Methods

Twenty-three PD

SUBMITTER: Quek DYL 

PROVIDER: S-EPMC11066616 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature