Subtractive genomics study for the identification of therapeutic targets against Cronobacter sakazakii: A threat to infants.

ABSTRACT: Cronobacter sakazakii is an opportunistic pathogen that has been associated with severe infection in neonates such as necrotizing enterocolitis (NEC), neonatal meningitis, and bacteremia. This pathogen can survive in a relatively dry environment, especially in powdered infant formula (PIF). Unfortunately, conventional drugs that were once effective against C. sakazakii are gradually losing their efficacy due to rising antibiotic resistance. In this study, a subtractive genomic approach was followed in order to identify potential therapeutic targets in the pathogen. The whole proteome of the pathogen was filtered through a step-by-step process, which involved removing paralogous proteins, human homologs, sequences that are less essential for survival, proteins with shared meta

SUBMITTER: Ahammad I 

PROVIDER: S-EPMC11066692 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature