The Alzheimer's Knowledge Base: A Knowledge Graph for Alzheimer Disease Research.

ABSTRACT:

Background

As global populations age and become susceptible to neurodegenerative illnesses, new therapies for Alzheimer disease (AD) are urgently needed. Existing data resources for drug discovery and repurposing fail to capture relationships central to the disease's etiology and response to drugs.

Objective

We designed the Alzheimer's Knowledge Base (AlzKB) to alleviate this need by providing a comprehensive knowledge representation of AD etiology and candidate therapeutics.

Methods

We designed the AlzKB as a large, heterogeneous graph knowledge base assembled using 22 diverse external data sources describing biological and pharmaceutical entities at different levels of organization (eg, chemicals, genes, anatomy, and diseases). AlzKB uses a Web Ontology Language 2 o

SUBMITTER: Romano JD 

PROVIDER: S-EPMC11066745 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature