Measurable Residual FLT3 Internal Tandem Duplication Before Allogeneic Transplant for Acute Myeloid Leukemia.

ABSTRACT:

Importance

Persistence of FLT3 internal tandem duplication (ITD) in adults with acute myeloid leukemia (AML) in first complete remission (CR) prior to allogeneic hematopoietic cell transplant (HCT) is associated with increased relapse and death after transplant, but the association between the level of measurable residual disease (MRD) detected and clinical outcome is unknown.

Objective

To examine the association between pre-allogeneic HCT MRD level with relapse and death posttransplant in adults with AML in first CR.

Design, setting, and participants

In this cohort study, DNA sequencing was performed on first CR blood from patients with FLT3-ITD AML transplanted from March 2013 to February 2019. Clinical follow-up was through May 2022. Data were analyzed from October

SUBMITTER: Dillon LW 

PROVIDER: S-EPMC11066770 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature