A database overview of metal-coordination distances in metalloproteins.

ABSTRACT: Metalloproteins are ubiquitous in all living organisms and take part in a very wide range of biological processes. For this reason, their experimental characterization is crucial to obtain improved knowledge of their structure and biological functions. The three-dimensional structure represents highly relevant information since it provides insight into the interaction between the metal ion(s) and the protein fold. Such interactions determine the chemical reactivity of the bound metal. The available PDB structures can contain errors due to experimental factors such as poor resolution and radiation damage. A lack of use of distance restraints during the refinement and validation process also impacts the structure quality. Here, the aim was to obtain a thorough overview of the distribution of

SUBMITTER: Bazayeva M 

PROVIDER: S-EPMC11066882 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature