Hypoxia-induced galectin-8 maintains stemness in glioma stem cells via autophagy regulation.

ABSTRACT:

Background

Glioma stem cells (GSCs) are the root cause of relapse and treatment resistance in glioblastoma (GBM). In GSCs, hypoxia in the microenvironment is known to facilitate the maintenance of stem cells, and evolutionally conserved autophagy regulates cell homeostasis to control cell population. The precise involvement of autophagy regulation in hypoxic conditions in maintaining the stemness of GSCs remains unclear.

Methods

The association of autophagy regulation and hypoxia was first assessed by in silico analysis and validation in vitro. Glioma databases and clinical specimens were used to determine galectin-8 (Gal-8) expression in GSCs and human GBMs, and the regulation and function of Gal-8 in stemness maintenance were evaluated by genetic manipulation in vitro and

SUBMITTER: Liu D 

PROVIDER: S-EPMC11066898 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature