Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance.

ABSTRACT:

Background

Cerebellar mutism syndrome (CMS) is a common and debilitating complication of posterior fossa tumor surgery in children. Affected children exhibit communication and social impairments that overlap phenomenologically with subsets of deficits exhibited by children with Autism spectrum disorder (ASD). Although both CMS and ASD are thought to involve disrupted cerebro-cerebellar circuitry, they are considered independent conditions due to an incomplete understanding of their shared neural substrates.

Methods

In this study, we analyzed postoperative cerebellar lesions from 90 children undergoing posterior fossa resection of medulloblastoma, 30 of whom developed CMS. Lesion locations were mapped to a standard atlas, and the networks functionally connected to each lesion

SUBMITTER: Suresh H 

PROVIDER: S-EPMC11066932 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature