C-di-AMP determines the hierarchical organization of bacterial RCK proteins.

ABSTRACT: In bacteria, intracellular K⁺ is involved in the regulation of membrane potential, cytosolic pH, and cell turgor as well as in spore germination, environmental adaptation, cell-to-cell communication in biofilms, antibiotic sensitivity, and infectivity. The second messenger cyclic-di-AMP (c-di-AMP) has a central role in modulating the intracellular K⁺ concentration in many bacterial species, controlling transcription and function of K⁺ channels and transporters. However, our understanding of how this regulatory network responds to c-di-AMP remains poor. We used the RCK (Regulator of Conductance of K⁺) proteins that control the activity of Ktr channels in Bacillus subtilis as a model system to analyze the regulatory function of c-di-AMP with

SUBMITTER: Rocha R 

PROVIDER: S-EPMC11067040 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature