Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population.

ABSTRACT:

Background

The human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical diseases and diverse in drug responses. High costs of HLA sequencing and the population-specific architecture of this genetic region necessitate the establishment of a population-specific HLA imputation reference panel. Moreover, there is a lack of understanding about the genetic and phenotypic landscape of HLA variations within the Taiwanese population.

Methods

We created models for a Taiwanese-specific HLA imputation reference panel. These models were trained with the array genotype data and HLA sequencing data from 845 Taiwanese subjects. HLA imputation was applied for 59,448 Taiwanese subjects to characterize the HLA allele

SUBMITTER: Chou WH 

PROVIDER: S-EPMC11067262 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature