Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina.

ABSTRACT: Increased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors. We further validated the senolytic and senomorphic properties of procyanidin C1 (PCC1) both in vitro and in vivo, the long-term treatment of which ameliorated age-related retinal impairment. Through high-throughput single-cell RNA sequencing (scRNA-seq), we comprehensively characterized the retinal landscape after PCC1 administration and deciphered the molecular basis underlying the senescence burden increment and elimination. By exploring the scRNA-seq da

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11067450 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature