Interactions between chaperone and energy storage networks during the evolution of Legionella pneumophila under heat shock.

ABSTRACT: Waterborne transmission of the bacterium Legionella pneumophila has emerged as a major cause of severe nosocomial infections of major public health impact. The major route of transmission involves the uptake of aerosolized bacteria, often from the contaminated hot water systems of large buildings. Public health regulations aimed at controlling the mesophilic pathogen are generally concerned with acute pasteurization and maintaining high temperatures at the heating systems and throughout the plumbing of hot water systems, but L. pneumophila is often able to survive these treatments due to both bacterium-intrinsic and environmental factors. Previous work has established an experimental evolution system to model the observations of increased heat resistance in repeatedly but uns

SUBMITTER: Liang J 

PROVIDER: S-EPMC11067923 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature