Role of the Ca_V1.2 distal carboxy terminus in the regulation of L-type current.

ABSTRACT: L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The Ca_V1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the Ca_V1.2 pore-forming subunit and auxiliary subunits like Ca_Vα₂δ and Ca_Vβ_2b. The Ca_V1.2 channel's C-terminus undergoes proteolytic cleavage, and the distal C-terminal domain (DC_termD) associates with the channel core through two domains known as proximal and distal C-terminal regulatory domain (PCRD and DCRD, respectively). The interaction between the DC_termD and the remaining C-terminus reduces the channel activity and modifies voltage- and calcium-dependent inact

SUBMITTER: Arancibia F 

PROVIDER: S-EPMC11067984 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature