Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson's disease.

ABSTRACT: Most individuals with Parkinson's disease experience cognitive decline. Mounting evidence suggests this is partially caused by cholinergic denervation due to α-synuclein pathology in the cholinergic basal forebrain. Alpha-synuclein deposition causes inflammation, which can be measured with free water fraction, a diffusion MRI-derived metric of extracellular water. Prior studies have shown an association between basal forebrain integrity and cognition, cholinergic levels and cognition, and basal forebrain volume and acetylcholine, but no study has directly investigated whether basal forebrain physiology mediates the relationship between acetylcholine and cognition in Parkinson's disease. We investigated the relationship between these variables in a cross-sectional analysis of 101 individual

SUBMITTER: Crowley SJ 

PROVIDER: S-EPMC11068112 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature