New-generation biofilm effective antimicrobial peptides and a real-time anti-biofilm activity assay: CoMIC.

ABSTRACT: Nowadays, it is very important to produce new-generation drugs with antimicrobial properties that will target biofilm-induced infections. The first target for combating these microorganisms, which are the source itself. Antimicrobial peptides, which are more effective than antibiotics due to their ability to kill microorganisms and use a different metabolic pathway, are among the new options today. The aim of this study is to develop new-generation antibiotics that inhibit both biofilm-producing bacteria and the biofilm itself. For this purpose, we designed four different peptides by combining two amino acid forms (D- and L-) with the same sequence having alpha helix structures. It was found that the combined use of these two forms can increase antimicrobial efficacy more than 30-fold. The

SUBMITTER: Polat T 

PROVIDER: S-EPMC11068671 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature