Designing function-specific minimal microbiomes from large microbial communities.

ABSTRACT: Microorganisms exist in large communities of diverse species, exhibiting various functionalities. The mammalian gut microbiome, for instance, has the functionality of digesting dietary fibre and producing different short-chain fatty acids. Not all microbes present in a community contribute to a given functionality; it is possible to find a minimal microbiome, which is a subset of the large microbiome, that is capable of performing the functionality while maintaining other community properties such as growth rate and metabolite production. Such a minimal microbiome will also contain keystone species for SCFA production in that community. In this work, we present a systematic constraint-based approach to identify a minimal microbiome from a large community for a user-proposed function. We em

SUBMITTER: Raghu AK 

PROVIDER: S-EPMC11068740 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature